Toxicology and pharmacokinetics

Toxicology determines the extent of any side effects seen in the body. The studies aim to evaluate the extent to which the drug substance in the drug candidate LIB-01 is expected to be safe for the user. Virtually all chemical substances are considered to have some toxic effect if the dose is high enough, the toxicology studies will also conclude what the maximum dose can be in future clinical trials.

Dicot's toxicological program consists of studies on rodents and non-rodents, which is a requirement from the pharmaceutical authorities. Rats and dogs are the most common laboratory animals used in this type of study.

Studies of a drug candidate's toxicity constitute a necessary and important part of the authorities' assessment prior to clinical trials and form the basis for Dicot's application for clinical trials in healthy human subjects.